利拉鲁肽与脂联素关系的研究进展

Research Progress of the Relationship between Liraglutide and Adiponectin

利拉鲁肽是一种人胰高血糖素样肽1类似物,有独特的作用机制,具有改善胰岛β细胞功能,促进胰岛β细胞分泌、减轻体质量等作用,不良反应少,是一种新型的降糖药,具有广阔的应用前景。脂联素是一种在脂肪细胞高度特异性表达、对人体有保护作用的脂肪因子,具有改善胰岛素抵抗、抗动脉粥样硬化、抑制炎症等作用,检测血清中脂联素的水平有重要意义。国内外在对小鼠的研究中发现,利拉鲁肽可能通过上调脂联素水平而改善胰岛素的敏感性。

Liraglutide is a GLP-1 analogue,its has a unique action mechanism which can improve 13-cell function, promote islet 13-cell secretion,lose weight and lessen adverse reactions. It is a new type of hypogly- cemic agent with broad application prospects. Adiponectin is a fat factor highly specificly expressed in the fat cells and has a protective effect, which has the function of improving insulin resistance, anti-atherosclerosis, inhibition of inflammation and so on. Detecting adiponectin level has an important significance. The study of mice at home and abroad found that liraglutide may improve insulin sensitivity through npregulation of adiponectin levels.