摘要
右美托咪啶是一种高选择性的α2肾上腺素受体(α2-AR)激动剂,通过激动分布于人体α2-AR,产生镇静、镇痛和抗焦虑作用,且无明显呼吸抑制作用。临床已广泛应用于术前麻醉、ICU麻醉和各种精细手术(神经外科手术、心血管外科手术)麻醉,甚至还可以应用于小儿镇静、麻醉。应用右美托咪啶还可以减少其他镇静、镇痛药物用量,降低不良反应发生的概率。右美托嘧啶临床应用优势明显,该文就右美托咪啶的研究进展和临床应用情况予以综述。
Dexmedetomidine is a highly selective ct2 adrenergic receptor（ct2-AR） agonist, which can keep patient in sedation, analgesia and anxiolysis without respiratory depression mainly through the ct2-AR all around the body. Dexmedetomidne has been used in preoperative anesthesia, ICU anesthesia, neurosurgery anesthesia, cardiovascular surgery anesthesia, and even pediatric anesthesia. Dexmedetomidne can reduce the dose of other sedative and analgesia drugs in clinical practice, and the risk of adverse reactions as well. Dexmedetomidne has many advantages in clinical application and here reviews the recent research progress and clinical application of dexmedetomidine.
出处
《医学综述》
2014年第2期317-319,共3页
Medical Recapitulate
关键词
右美托咪啶
镇静
镇痛
抗焦虑
Dexmedetomidine
Sedation
Analgesia
Anxiolysis
