七氟烷对肺缺血/再灌注保护作用及机制的研究进展

Research Progress in the Protection Function and Mechanism of Sevoflurane on Lung Ischemiareperfusion Injury

肺缺血/再灌注损伤存在于心胸外科手术术后以及失血性休克等的过程中,其对患者的恢复存在极大影响。七氟烷除具有诱导快、苏醒迅速、呼吸道刺激小等麻醉效能外,对肺脏缺血/再灌注损伤亦存在保护作用,其机制尚有争议。七氟烷可通过抑制中性粒细胞的聚集、炎性因子的表达等表现出肺保护作用。与其他麻醉药相比,七氟烷通过缺血预处理样作用产生保护作用。该文对该方面研究进展进行综述,旨在为揭示七氟烷肺脏保护作用的分子机制研究提供思路,为临床手术麻醉用药提供理论依据。

Lung ischemia-reperfusion injury exists in heart surgery, thoracic surgeries and hemorrhagic shock, which has great influence on the recovery of the patients. Sevoflurane is a new type of volatile anesthetics with the characteristics of rapid narcotic induction, fast recovery and less respiratory stimulation. Some Studies have reported sevoflurane has protection effect on ischemia-reperfusion, though the mechanisms are still controversial. Sevoflurane protects the lung against ischemia and reperfusion injury by many mechanisms, including both effectively inhibiting the aggregation of polymorphonuclear cell adherence and inflammatory factor expression. Compared with other anesthetics, sevoflurane produced the protective effect by ischemic preconditioning-like effect. Here is to make a review of the research progress in the field,in order to provide ideas for the molecular mechanisms of sevoflurane protection on lungs, and provide theoretical basis for the surgery anesthesia.