摘要
肺癌是当前最常见的恶性肿瘤之一,其发病率和死亡率均逐年升高。肺癌对人类健康的危害日益加重,因此对肺癌诊断和治疗的要求更加迫切。肺癌的发生、发展涉及复杂的生物学过程,主要包括抑癌基因的失活和原癌基因的激活,因此深入了解与肺癌相关的基因的作用和机制很有必要。随着分子生物学的迅速发展,人们对肺癌中相关发病基因有了更深刻的认识,现就肺癌相关的抑癌基因(如p53、Rb、p16、LKB1、PTEN、4.1B/DAL-1、GPRC5A、GATA、PTPRO)作一简要概述。
Lung cancer is one of the most common malignant tumors with increasing morbidity and mortality in recent years. Because the harm of lung cancer on human health is becoming ever more prominent, the ef- fective diagnosis and treatment are very essential. The occurrence and development of lung cancer is a series of complex biological processes,including inactivation of anti-oncogenes and activation of proto-oncogenes. So it is very important to explore the genes involved in lung cancer. With the rapid development of molecu- lar biology, more and more genes related to lung cancer have been revealed. The recent research progress of tumor suppressor genes （such as p53,Rb ,p 16,LKB1 ,PTEN and 4.1B/DAL-1, GPRC5A, GA TA, PTPRO） relat- ed to lung cancer are summarized.
出处
《生命科学研究》
CAS
CSCD
北大核心
2014年第1期83-89,共7页
Life Science Research
基金
国家自然科学基金资助项目(81270576)
教育部新世纪优秀人才计划项目(NCET-11-0518)
高等学校博士学科点专项科研基金资助项目(20120162110054)
湖南省自然科学基金资助项目(12JJ5054)
中南大学研究生米塔尔项目(12MX20)
中央高校基本科研业务费资助项目(2011JQ015)
关键词
肺癌
抑癌基因
诊断
治疗
lung cancer
tumor suppressor genes
diagnosis
therapy
