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3-硝基-4-羟基苯甲酸的制备研究 被引量：1

Study on preparation of 3-nitro-4-hydroxyl benzoic acid
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摘要 以3-硝基-4-氯苯甲酸为原料,经水解反应得到产品,最佳水解条件为:氢氧化钠/3-硝基-4-氯苯甲酸摩尔比为4.5,碱液质量分数为15%,水解温度为95℃,反应时间为10 h。在最佳水解条件基础上,考察了碱液的循环利用,提高了氢氧化钠的利用率。总收率大于91%,纯度大于99%(HPLC),经FTIR、1H NMR、13C NMR和MS分析,证实产品为3-硝基-4-羟基苯甲酸。 3-Nitro-4-hydroxybenzoic acid was synthesized from 3-nitro-4-chlorobenzoic acid through hydro- lyzation in sodium hydroxide solution. Best result was obtained under conditions of reaction temperature of 95 ℃, molar ratio of sodium hydroxide to 3-nitro-4-chlorobenzoic acid of 4.5, mass concentration of sodium hydroxide of 15% ,reaction time of 10 h. Based on the optimized process, the recycle of sodium hydroxide was studied. High yield （ 〉 91% ） ,high purity （ 〉 99% HPLC was achieved. The structure of the title compound was confirmed by 1H NMR,13C NMR,FTIR and MS.
作者 全保学 蒋文伟 杨琴
机构地区 四川大学化学工程学院 成都惠恩精细化工有限责任公司
出处 《应用化工》 CAS CSCD 2014年第2期332-334,共3页 Applied Chemical Industry
关键词 3-硝基-4-羟基苯甲酸 3-硝基4-氯苯甲酸 水解 循环 3-nitro-4-hydroxyl benzoic acid 3-nitro-4-chloro benzoic acid hydrolyzation recycle
分类号 TQ216 [化学工程—有机化工]
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参考文献7

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同被引文献12

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应用化工
2014年 第2期

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