加味甘露消毒饮治疗早期脂肪性肝病的临床研究

Clinical Study on Modified GanLu XiaoDu Drink in Treating Fatty Liver Disease at Early Stage

目的:观察加味甘露消毒饮治疗早期脂肪性肝病的疗效及作用机理。方法:治疗组48例采用加味甘露消毒饮治疗,1剂/d,水煎2次,分早晚2次口服,随证或随病加减;对照组45例单纯口服复方蛋氨酸胆碱片治疗,3片/次,3次/d。治疗3个月后观察2组患者疗效以及ALT、AST、TC、TG各项指标变化情况。结果:总有效率治疗组为91.7%,对照组为75.6%;治疗组治疗后肝功(ALT、AST)、血脂(TC、TG)各项指标均有不同程度改善(P<0.05),与对照组治疗后比较有显著性差异(P<0.05)。结论:加味甘露消毒饮治疗早期脂肪性肝病的疗效优于复方蛋氨酸胆碱片。

Objective：To observe the effects of modifies GanLu XiaoDu drink in treating fatty liver disease and its mechanism. Methods：Altogether 48 cases of the treatment group took modified GanLu XiaoDu drink, one dose per day, decocted in water for twice, taking in the morning and evening, modified according to the syndrome or the disease. 45 cases of the control group compound methionine and choline bitartrate tablets, three pills each time, three time pre day. Therapeutic effects of both groups, the changes of ALT, AST, TC and TG were observed after treating for three months. Results：Total effective rate of the treatment group was 91.7%, higher than 75.6%of the control group. Liver functions （ALT and AST） and blood lipid （TC and TG） of the treatment group were improved in the treatment group in different degrees （P＆lt;0.05）, it had significant difference compared with the control group after treating （P＆lt;0.05）. Conclusion：Modified GanLu XiaoDu drink in treating fatty liver disease is more effective than compound methionine and choline bitartrate tablets.