Src蛋白在膀胱移行细胞癌上的表达及其意义

Expression of Src Protein in Bladder Transitional Cell Carcinoma and Its Significance

[目的]探讨Src蛋白在膀胱移行细胞癌（BTCC）组织中的表达及其意义。[方法]采取 HE染色和半定量RT-PCR检测c-Src基因在BTCC、癌旁组织及正常膀胱组织中的表达。[结果]BTCC（分浅表性膀胱癌和肌层浸润性膀胱癌两组）组织中c-Src基因在mRNA表达水平上明显增高，而在癌旁组织及正常膀胱组织中表达较低。c-Src mRNA的表达水平与BTCC患者肿瘤临床分期、病理分级，以及肿瘤有无复发具有相关性；其表达的强度与膀胱肿瘤的分化和分期密切相关，分化越低、临床分期越晚以及复发患者，其过表达越明显。[结论]c-Src的过表达或高表达与BTCC的侵袭、复发和转移密切相关。

[Objective] To explore the expression of Src protein in bladder transitional cell carcinoma （BTCC） and its clinical significance .[Methods] The expression of c-Src gene in BTCC ,adjacent cancer tissue and normal bladder tissue was detected by HE staining and semi-quantitative RT-PCR .[Results] The expres-sion of c-Src mRNA in BTCC tissue （superficial BTCC and muscular infiltrated BTCC ） obviously increased , while that in adjacent cancer tissue and normal bladder tissue decreased .The expression of c-Src mRNA was correlated with tumor clinical stage ,pathological grade and tumor recurrence of BTCC patients .The intensity of c-Src expression was closely related to tumor differentiation and stage .The patients with low differentia-tion ,late clinical stage and recurrence had obvious over-expression of c-Src .[Conclusion] Over-expression or high expression of c-Src is closely related to invasion ,recurrence and metastasis of BTCC .