胱抑素C在评价2型糖尿病患者肾功能中的应用价值

Value of Cystatin C for the Evaluation of Renal Function of Type 2 Diabetes Mellitus

[目的]探究血清胱抑素C（Cysc）在评价2型糖尿病（T2DM）患者肾功能中的应用价值。[方法]选取T2DM患者95例，依据尿蛋白分为无蛋白尿组（A组）40例，微量白蛋白尿组（B组）34例，临床蛋白尿组（C组）21例，使用免疫比浊法测定患者的空腹血肌酐（SCr）与血清CysC水平并计算肌酐清除率（CCr）。[结果]B、C组患者血清SCr、CysC水平均高于A组，CCr水平低于A组（P〈0．05），CCr随蛋白尿程度加重而下降。B、c组患者血清SCr、CysC水平与CCr呈负相关（P〈0．01），且B组患者中，CysC与CCr的相关性更强（P〈0．01）。[结论]血清CysC可以作为评价糖尿病肾病患者肾功能的指标，尤其适用于早期糖尿病肾病患者。

[Objective]To explore the value of cystatin C（Cys C） for assessing renal function of patients with type 2 diabetes mellitus（T2DM）. [Methods] According to urinary protein, 95 T2DM patients were di- vided into non-proteinuria group（group A, n = 40）, microalbuminuria group （group B, n = 34） and clinical proteinuria group（group C, n =21）. Immune turbidimetry was used to measure the fasting serum creatinine （SCr） and serum Cys C. Creatinine clearance（CCr） was calculated. [Results] Serum SCr and Cys C of group B and group C were higher than those in group A, while CCr in group B and group C was lower than that in group A（ P 〈0.05）. CCr decreased with the severity of proteinuria. In group B and group C, serum SCr and Cys C were negatively correlated with CCr（ P〈0.01）. Especially in group B, the correlation between Cys C and CCr was stronger（ P 〈0.01）. [Conclusion]Serum Cys C can be used as indicators of the evaluation of re- nal function in patients with diabetic nephropathy, especially for patients with early diabetic nephropathy.