H—rev107、TIG3、PSA在前列腺癌患者精浆及血清中的表达及其相关性

Expression of H-rev107, TIG3 and PSA in Seminal Plasma and Serum of Patients with Prostate Carcinoma and Their Correlation

[目的]探讨前列腺癌患者精浆和血清中抑癌因子H-rev107和TIG3的表达水平及其与前列腺特异性抗原（PSA）的相关性。[方法]ELISA法检测前列腺癌患者（试验组）和健康男性（对照组）血清及精浆中H-rev107、TIG3及PSA的表达水平。[结果]试验组血清中H-rev107、TIG3及PSA表达均高于对照组（均P〈0．05），H-revl07和TIG3分别与PSA在血清中的水平呈正相关。精浆中H-rev107的表达试验组高于对照组（P〈0．05），但其TIG3和PSA表达两组间比较无统计学意义（P〉0．05）。[结论]抑癌因子H-rev107和TIG3均表达于前列腺癌的血清及精浆中，H-rev107在血清及精浆均有较高的表达，H-rev107和TIG3分别与PSA在血清中的水平呈正相关。

[Objective] To explore the expressions of tumor suppressors H-rev107 and TIG3 in seminal plasma and serum Of patients with prostate carcinoma and their correlation with prostate-specific antigen（PSA）. [Methods] ELISA was used to detect the expression levels of H-rev107, TIG3 and PSA in serum and seminal plasma of patients with pros- tate carcinoma（experimental group） and healthy men（control group）. [Results] The expression levels of serum H- rev107, TIG3 and PSA in experimental group were higher than those in control group（all P 〈0.05）. Serum levels of H- rev107 and TIG3 were positively correlated with PSA, respectively. The expression of H-rev107 in seminal plasma of ex- perimental group was higher than that in control group（ P 〈0.05）, but there was no significant different in the expres- sion of TIG3 and PSA between two groups（ P 〉0. 05）. [Conclusion] Tumor suppressors H-rev107 and TIG3 are ex- pressed in serum and seminal plasma of prostate cancer. H-rev107 and TIG3 in serum are positively correlated with PSA, respectively.