硫辛酰维格列汀对2型糖尿病(T2DM)大鼠降糖作用的研究

Study on hypoglycemic effects of lipoyl vildagliptin in type 2 diabetic rats

目的观察硫辛酰维格列汀对2型糖尿病大鼠血糖的影响。方法选用雄性Wistar大鼠，高脂高糖饲料喂养4周后小剂量注射链脲佐菌素建立2型糖尿病模型，随机将大鼠分为正常对照组、糖尿病模型组、胰岛素糖尿病组、硫辛酰维格列汀糖尿病组。分别测定给药后0、0．5、1、2、3、4、5、6、7、8、9、10、12、24h的血糖变化。结果注射链脲佐菌素72h后造模大鼠血糖均明显高于注射前（P％0．05）和正常对照组（P〈0．05）。与正常对照组和糖尿病模型组相比，胰岛素糖尿病组在注射胰岛素后0．5～4h，血糖变化差异有统计学意义（P〈0．05）；硫辛酰维格列汀糖尿病组在灌胃给药3～10h，血糖变化差异有统计学意义（P〈0．05）。结论硫辛酰维格列汀和胰岛素有不同程度的降血糖作用，相比胰岛素，硫辛酰维格列汀降糖作用更加持久。

Objective To investigate the effects of lipoyl vildagliptin on the blood glucose level in Streptozotocin-induced diabetic Wistar rats. Methods Wistar rats were fed with high-fat and high-glucose diet for four weeks, then were injected with streptozotocin to form the T2DM rats. These rats were randomly divided into four groups： control group, T2DM sham group, T2DM insulin treated group, T2DM lipoyl vildagliptin treated group. Blood glucose level changed after intragastric administration of lipoyl vildagliptin, then the blood glucose level was detected on 0, 0.5,1,2,3,4,5,6,7,8,9,10,12,24h. Results Blood glucose after streptozotocin injection was significantly higher than before injection （P 〈 0.05 ） and control group （P 〈 0.05）. Comparing with control group and T2DM control group, the blood glucose level changes had statistical significance（P〈0.05） after injected insulin 0-4h later; the blood glucose level changes had statistical significance（P〈0.05） after intragastrie administration 3-10h. Conclusion Lipoyl vildagliptin has hypoglycemic effects in the type 2 diabeticrat, and the hypoglycemic effect of lipoyl vildagliptin is more abiding than insulin.