Rho鸟嘌呤核苷酸交换因子家族及其在疾病发生中的作用

RhoGEF Family and the Role in Occurrence and Development of Diseases

Rho GTP酶(Rho GTPase)家族在真核生物细胞中参与细胞骨架调节、基因转录、膜泡运输等过程,扮演着分子开关的角色。Rho型鸟嘌呤核苷酸交换因子(RhoGEF)是调节Rho GTPase活性的关键因子,在Rho GTPase信号调节、组织器官的生长发育及免疫应答中起着至关重要的作用。RhoGEF与肿瘤、发育及神经类疾病、病原微生物感染等也有密切关系,对其功能的深入了解有助于人们认识某些生理和病理现象的发生机制。

Rho GTPases family plays a role of molecular switch in many cellular processes, including cytoskeletal dynamics, vesicle trafficking and gene transcription. Guanine nucleotide exchange factors （ RhoGEFs ） are the key regulator of activity for Rho GTPases. RhoGEFs can regulate signal transduction of Rho GTPases, development of tissues or organs and immune response. RhoGEFs are associated with cancer, development or neural system related diseases and pathogen infection, understanding of its function will help us to verify the mechanisms of some physiological and pathological process.