通腑净化汤对创伤后炎症反应的影响

Effect of Tongfu Jinghua Decoction on Post-traumatic Inflammation

目的:探讨通腑净化汤对创伤后炎症反应的影响。方法:将60例开放性骨折并伴有发热患者分为2组各30例,治疗组给予通腑净化汤保留灌肠,对照组给予温水保留灌肠,观察2组退热疗效、急性生理学与慢性健康状况Ⅱ(APACHEⅡ)评分、CD4+CD25+调节性T细胞的表达。结果:退热疗效总有效率治疗组为96.7%,对照组为66.7%,2组比较,差异有显著性意义(P<0.05)。伤后第5、8天,治疗组APACHEⅡ评分均明显低于对照组,差异均有非常显著性意义(P<0.01)。伤后第8天,2组CD4+CD25+调节性T细胞表达均较伤后1天明显升高,差异均有显著性意义(P<0.05);且治疗组CD4+CD25+调节性T细胞表达高于对照组,差异有显著性意义(P<0.05)。结论:通腑净化汤对于创伤后发热患者退热效果明显,可促进患者调节性T细胞增殖,从而维持炎症平衡。

Objective： To explore the effect of TonJu Jinghua Decoction on post-traumatic inflammation. Methods： Sixty open fracture patients complicated with fever were evenly divided into treatment group and control group. The treatment group was given retention enema with Tongfu Jinghua Decoction, and the control group was given retention enema with warm water. Antipyretic efficacy was compared between the two groups, The scores of acute physiology and chronic health evaluation II （APACHE II） as well as the expression of CD4＋ CD25＋ regulatory T cells were observed in the two groups. Results： Antipyretic efficacy in the treatment group was 96.7% and was 66.7% in the observation group, the difference being statistically significant（P 〈 0.05）. On post-traumatic day 5 and 8, APACHE II scores in the treatment group were lower than those in the control group（P 〈 0.01）, indicating that the illness state was milder in the treatment group. On post-traumatic day 8, the expression levels of CD4＋CD25＋ regulatory T cells were increased in the two groups compared with those on post-traumatic day one（P 〈 0.05）, and the increase in the treatment group was superior to that in the control group （P 〈 0.05）. Conclusion： TonJu 2inghua Decoction has markedly antipyretic efficacy on post-traumatic patients complicated with fever, and its possible mechanism is related with the enhancement of regulatory T cells proliferation, thereby maintaining inflammation balance.