摘要
C5a受体是人和动物体内补体系统的重要组成部分,与C5a结合后介导了众多生物学效应,参与了许多疾病的发生、发展,并在多种病变中起重要作用,如器官缺血再灌注损伤、急性肺损伤、脓毒血症、类风湿性关节炎、肾小球肾炎等疾病。如何抑制C5a受体的生物活性,从而减轻炎症反应一直是免疫学研究的热点问题。文章着重介绍了C5a受体颉颃剂及其在动物疾病模型治疗中的研究进展。
As a key part of the complement system in human and animal body, CSa receptor combined with C5a has been considered to mediate numerous biological processes and be involved in the pathology of numerous inflammatory diseases, such as ischemia-reperfusion injury, acute lung injury, sepsis, rheumatoid arthritis and glomerular nephritis. Therefore, current studies focus on how to block CSa receptor and dampen the inflammatory reaction. This review provides a brief overview of the current development of CSa receptor antagonists and their treatment in animal disease model.
出处
《中国畜牧兽医》
CAS
北大核心
2014年第2期158-163,共6页
China Animal Husbandry & Veterinary Medicine
基金
国家自然科学基金(31070776)
