微血管密度和中期因子在宫颈上皮内瘤变及宫颈鳞癌患者中的表达及其意义

Expressions and significances of microvessel density and midkine in patients with cervical intraepithelial neoplasia and cervical sqamous cell carcinoma

目的:探讨微血管密度和中期因子在宫颈上皮内瘤变及宫颈鳞癌患者中的表达,并分析其临床意义。方法:选择宫颈上皮内瘤变患者22例、宫颈鳞癌患者28例及22例子宫内膜组织正常患者为研究对象,对比分析其微血管密度和中期因子表达情况。结果:中期因子表达阳性子宫内膜正常组0例,宫颈上皮内瘤变组5例,宫颈鳞癌组14例,各组间差异有统计学意义(P<0.05)。微血管密度子宫内膜正常组中为(7.7±4.9),宫颈上皮内瘤变组中为(10.6±5.6),宫颈鳞癌组中为(25.1±8.4),各组间差异有统计学意义(P<0.05)。结论:中期因子的阳性表达和微血管密度与宫颈上皮内瘤变及宫颈鳞癌密切相关,可作为宫颈癌变的监测指标。

Objective： To explore the expressions of microvessel density （MVD） and midkine in patients with cervical intraepittle- lial neoplasia （CIN） and cervical sqamous cell carcinoma, and analyze their clinical significances. Methods： The expressions of MVD and midkine in 22 patients with CIN, 28 patients with cervical squamous cell carcinoma, and 22 patients with normal endometrial tissue （control group） were compared and analyzed. Results： The numbers of patients with positive midkine in control group, CIN group, and cervical sqamous cell carcinoma group were 0, 5, and 14, respectively, there was statistically significant difference among the three groups （ P 〈 0. 05） ; the values of MVD in control group, CIN group, and cervical sqamous cell carcinoma group were （7.7 ±4. 9）, （10. 6 ±5.6）, and （25. 1 ± 8.4）, respectively, there was statistically significant difference among the three groups （P 〈 0. 05 ） . Conclusion： Positive expression of midkine and MVD are closely cmxelated with CIN and cervical sqamous cell carcinoma, which can be used as monitoring indexes of cervical carcinogenesis.