PGP9.5和NPY在女性SUI患者阴道壁组织中的表达及意义

Expressions and significances of PGP9. 5 and NPY in vaginal wall tissue of women with stress urinary incontinence

目的:探讨女性压力性尿失禁(SUI)患者阴道壁组织中蛋白基因产物9.5(PGP9.5)及神经肽Y(NPY)的表达变化,分析神经表达与疾病发生的关系。方法:随机选取45例有完整随访资料的女性SUI患者为SUI组,并选取同期30例非卵巢功能性肿瘤和宫颈病变患者为对照组,均于术中取患者阴道前壁尿道中段处粘膜结缔组织。采用半定量免疫组化法观察阴道前壁组织中的蛋白基因产物PGP9.5和NPY表达情况。结果:SUI组PGP9.5和NPY的表达为115.255±5.644和114.309±4.011,较对照组130.035±4.030和141.512±3.810明显下降,两组之间差异有统计学意义(P<0.05)。结论:女性阴道前壁组织分布着PGP9.5和NPY肽能神经纤维,SUI患者存在PGP9.5和NPY低表达,盆底神经源性损伤可能是SUI重要发病机制之一。

Objective： To explore the changes of expressions of protein gene product 9. 5 （ PGP9. 5 ） and neuropeptide Y （NPY） in vaginal wall tissue of women with stress urinary incontinence （ SUI）, analyze the relationship between their expressions and occurrence of SUI. Methods： Forty - five female patients with SUI and intact follow - up data were randomly selected as SUI group, and thirty patients with non -ovarian function tumors and cervical lesions during the same period were selected as control group; the mucosal connective tissue specimens of middle urinary tract on front vaginal wall were obtained during operation ; semi - quantitative immunohistochemical method was used to observe the expressions of PGP9. 5 and NPY on the front vaginal wall. Results： The expression levels of PGP9. 5 and NPY in SUI group were （ 115. 255 ± 5. 644 ） and （ 114. 309 ± 4. 011 ）, respectively, compared with control group [ （ 130. 035 ± 4. 030） and （ 141.512 ± 3. 810） ], which decreased significantly, there were statistically significant differences （P 〈 0. 05） . Conclusion： PGP9. 5 and NPY nerve fibers are found on the front vaginal wall of women, and down - regulations of PGP9. 5 and NPY exist in patients with SUI, pelvic neurogenic injury may be one of important causes of SUI.