微生物合成白藜芦醇的研究进展

Advances on resveratrol production of engineered microorganisms

白藜芦醇是植物源的多酚化合物,具有清除自由基、抗氧化、延长寿命等生理活性,在医药、保健品、化妆品等方面有着广阔的应用前景。目前,白藜芦醇主要采用植物提取的方法,对自然植物资源依赖严重,而且受植物成分含量和提取效率低的限制。近年来,合成生物学的迅速发展已使人们将注意力转向利用微生物合成白藜芦醇。通过在微生物中转入外源基因,成功构建出了白藜芦醇工程菌株,并从基因序列、组合方式及发酵工艺等方面进行了优化改造。本文综述了微生物合成白藜芦醇的研究进展。

Resveratrol, a plant-derived polyphenolic compound, has significant physiological activities, including scavenging free radicals, antioxidant and extending lifespan. It has a pleasing market for health products, cosmetics and medicines. At present, resveratrol is mainly extracted from plant, which is limited by the low concentration and extraction efficiency. The rapid development of synthetic biology gives a new approach to produce resveratrol using microogrganisms. Resveratrol has been biosynthesized through introducing exogenous genes into microorganisms. Moreover, the recombinant strains are optimized in encoding sequences and combination of genes with suitable fermentation process control. This paper outlines the research achievement on resveratrol production in engineered microorganisms.