口腔托盘给药系统在口腔医学中的应用

Application of the dental drug delivery system in stomatology

口腔托盘给药系统(DDDS)是在专业机械洁牙后用托盘局部输送药物的一种联合应用物理化学途径的口腔给药方法。DDDS由有储药池之称的个别托盘组成,贴附在牙体表面,借助于托盘的良好封闭作用,直接向牙体表面输送小剂量药物,使药物长时间保持有效的质量浓度,起到良好的治疗作用。通过DDDS给药,药物可长时间地保持有效质量浓度;减少口腔味觉改变、口腔烧灼感和细菌耐药情况的发生;用药灵活,可根据病情调整用药周期和药物配方;疗程可长可短,给药及移除药物方便。患者在家庭或办公时自行戴用托盘给药,减少了复诊次数,不会因复诊问题中断或延缓治疗。本文就DDDS托盘的制作,DDDS的使用,DDDS在牙体漂白中的应用、在治疗牙周病中的应用、在牙本质过敏治疗中的应用、在防龋中的应用等研究进展作一综述。

The dental drug delivery system（DDDS）, in combination with professional mechanical tooth cleaning and local application of drugs using trays, may be used as a physicochemical method to deliver drugs. The DDDS consists of individual trays called drug retainers that come in contact with the tooth surface and deliver drugs. The application maintains clinical efficacy and reduces altered taste, burning sensation, and drug-resistance in the mouth. The system can easily adjust the drugs and medication cycle. The treatment can be long or short, and removing the drugs can be convenient. Patients can wear their own trays at home or in the office, and they need not set up appointments. The tray fabrication, method of application, and current application of DDDS in tooth bleaching, treatment of periodontal disease, treatment of dentine hypersensitivity, and prevention of dental caries are reviewed in this article.