中药炮制机制研究进展及研究思路探讨

Discussion about research progress and ideas on processing mechanism of traditional Chinese medicine

中药炮制机制研究是中药炮制学和中药现代化的关键。目前中药炮制机制研究主要采用化学和药理学的方法,探讨中药炮制后增效、减毒、缓性或生熟异治的原理,从而使中药饮片的炮制机制取得了突破性进展。随着现代科学技术的引入,生物转化、肠吸收转运、药代动力学以及代谢组学等新方法开始逐步应用于中药炮制机制研究。该文通过总结近年来中药炮制机制研究领域的成果,分析和探讨其中存在的主要问题,指出应从吸收代谢角度深入研究中药炮制机制、加强炮制辅料的作用机制研究、注重多学科结合与数据统计分析。同时结合课题组多年的探索和实践,提出"基于化学成分转化-肠吸收屏障网络耦联作用的中药炮制机制研究"新思路,为中药炮制机制研究提供了借鉴和参考。

Study on the processing mechanism of traditional Chinese medicine is the key to science of processing Chinese materia medica and modernization of traditional Chinese medicine. At present, chemical and pharmacology methods are mainly used to discuss the processing principle of efficiency, attenuated, delayed or cooked with different treatment. So that the processing mechanism of Chinese herbal medicine has made breakthrough progress. With the introduction of modern science and technology, biotransformation, intestinal absorption, pharmacokinetics and metabolomics methods have been gradually applied in traditional Chinese medicine processing mechanism. This article summarizes the achievements in the processing mechanism of traditional Chinese medicine in recent years, analyses and discusses some main problems, and points out to in-depth study on absorption and metabolism, strengthening excipient processing mechanism, paying attention to the integration of multiple disciplines and data statistical analysis. Combined with years of exploration and practice, the project group proposes a new idea ＂traditional Chinese medicine processing mechanism based on coupled effect of chemical composition transformation and intestinal absorption barrier＂ , which provides reference for the study of the mechanism of traditional Chinese medicine processing.