基于体内自组装胶束形成机制的羊脂油炙淫羊藿增效机制研究思路与探讨

Discussion on research ideas of synergistic mechanism of Epimedium fried with suet oil based on self-assembled micelles formation in vivo

应用辅料炮制中药,是我国传统制药技术的一大特色。如何采用现代科学技术揭示辅料炮制的科学内涵,是中药炮制研究的核心。淫羊藿为传统补益类中药,经羊脂油制后可增强温肾助阳的作用。然而目前文献研究从化学成分和药理作用2个方面尚不能全面解释辅料羊脂油的炮制机制。该文结合羊脂油所含脂肪酸类成分具有脂肪长链和表面活性的特点,并基于自组装药物传递系统的理论基础,以及淫羊藿黄酮自组装胶束模拟形成和促吸收的实验基础,创新性提出基于"自组装胶束"体内形成机制研究羊脂油炙淫羊藿的作用机制假说,同时详细阐述了自组装胶束对淫羊藿黄酮促吸收作用和增效机制的研究思路和方法,对揭示中药"油炙"的科学内涵具有重要的理论意义和应用价值。

Accessories processing is a major feature of traditional pharmaceutical technology in China. How to use modem science and technology to reveal the scientific connotation of accessories processing, is the core of traditional Chinese medicine processing research. As traditional beneficial Chinese medicine, Epimedium can enhance the effect of warming kidney yang after processing with suet oil. However, the current literature research from two aspects of chemical constituents and pharmacological action cannot fully explain the processing mechanism of accessories suet oil. According to the characteristics of fatty acids in suet oil with long chain fatty and surface activity, and based on the theoretical basis of self-assembled drug delivery system, as well as the experimental basis of Epimedium flavonoids self-assembled micelles simulated formation and promoting absorption, this paper puts forward the research hypothesis on synergistic mechanism of Epimedium fried with suet oil based on self-assembled micelles formation in vivo. This paper also describes in detail the research ideas and methods of self-assembled micelles enhancing absorption and synergistic mechanism of Epimedium flavonoids, which has the important theory significance and application value to reveal the scientific connotation of Chinese medicine fried with oil.