Nano-Au/Silica sol/PVP修饰金电极上电化学发光测定盐酸硫必利

Determination of Tiapride Hydrochloride Based on Nano-Au/Silica sol/PVP Modified Gold Electrode by Electrochemiluminescence

采用溶胶-凝胶法制备了Nano—Au／Silicasol／PVP修饰金电极，并基于盐酸硫必利对联吡啶钌（Ru（bpy）2/3＋）在该修饰电极上弱电化学发光具有较强的增敏作用，建立了电化学发光检测盐酸硫必利的新方法。在最佳实验条件下，盐酸硫必利浓度在1．0×10-7～1．0×0-4mol／L范围内与相对发光强度呈线性关系（r2=0．9978），检出限（S／N-3）为6．7×10-10mol／L。连续平行测定1．0×10-5mol／L盐酸硫必利溶液10次，发光强度的相对标准偏差（RSD）为1．789／6。对样品进行回收率试验，其回收率在97．7％～103．9％之间，RSD为2．62％。该方法具有较高的选择性和灵敏度，样品处理简单快速，用于盐酸硫必利的测定，结果满意。

A Nano-Au/Silica sol/PVP modified gold electrode was prepared. Based on the obvious electrochemiluminescence sensitization effect of tiapride hydrochloride on Ru（bpy）2/3＋ on the modified electrode,a new electrochemiluminescence method for the determination of tiapride hydrochloride was developed. Under the optimum condition, the calibration curve showed a good linearity with tiapride hydrochloride concentration in the range of 1.0 × 10-7-1.0 × 10-4 mol/L（r2 = 0. 9978） and the detection limit（S/N= 3） was 6.7 × 10-1μ mol/L. The RSD for 10 times determination of 1.0 × 10-s mol/L tiapride hydrochloride was 1.78 %, recoveries was in the range of 97.70%- 103.9 % and the RSD was 2.62 %. The proposed method showed high selectivity and sensitivity and simplicity. This method was applied to the analysis of Tiapride Hydrochloride tablet with satisfactory results.