多囊卵巢综合征不孕患者血清Apelin水平与胰岛素抵抗的关系

Relation between serum Apelin level and insulin resistance in infertility patients with polycystic ovarian syndrome

目的:研究多囊卵巢综合征(PCOS)不孕患者血清Apelin水平的变化及其与胰岛素抵抗(IR)的关系。方法:选择2011年1月至2012年6月间首次来我院就诊的98例PCOS不孕患者及72例非PCOS不孕患者,分别分为PCOS组和非PCOS组。分别比较两组患者的体重指数(BMI)、血清Apelin、血糖、胰岛素、稳态模型胰岛素抵抗指数(HOMA-IR)间的相互关系。血清Apelin采用ELISA法测定,空腹血浆葡萄糖(FPG)采用葡萄糖氧化酶法测定,空腹胰岛素(FIns)采用化学发光法测定。结果 :PCOS组血清Apelin水平(μg/L)明显高于非PCOS组(3.28±1.24 vs.1.94±0.78,P<0.05)。PCOS组的HOMA-IR高于非PCOS组(3.84±1.23 vs.2.14±0.77,P<0.05);Person相关分析表明,PCOS组血清Apelin水平与HOMA-IR相关(r=0.65,P<0.01)。结论 :PCOS不孕患者血清Apelin水平升高,并且其升高与IR密切相关。提示Apelin可能参与PCOS不孕患者IR的发生发展。

Objective To explore the change of serum Apelin level and its relationship with insulin resistance （IR） in infertility patients with polyeystic ovarian syndrome （PCOS）. Methods Ninety-eight infertility patients with PCOS （PCOS group） and 72 infertility patients without PCOS （non-PCOS group） visiting our hospital for the first time from January 2011 to June 2012 were selected. The BMI, serum Apelin level （detected by ELISA）, fasting blood glucose （FPG, detected by glucose oxidase method）, fasting insulin （Fins, detected by chemiluminescence）, and homeostasis model assessment of insulin resistance index （HOMA-IR） of the two groups were detected. Results The serum Apelin level and HOMA-IR in PCOS patients were higher than those in non- PCOS patients （3.28± 1.24 vs. 1.94 ± 0.78, P 〈 0.05; 3.84± 1.23 vs. 2.14 ± 0.77,P 〈 0.05）. Pearson correlation analysis showed that serum Apelin level was positively correlated with HOMA-IR in PCOS patients （r =0.65, P 〈 0.01 ）. Conclusions The serum Apelin level in infertility patients with PCOS increased evidently, and was positively correlated with HOMA-IR; which indicated that Apelin may involve in the development of IR in infertility patients with PCOS.