阿司匹林铜(Ⅱ)配合物的合成、晶体结构和抗肿瘤活性

Synthesis,Characterization and Antitumor Activities of Cu(Ⅱ)-Aspirin Complex

合成了阿司匹林铜(Ⅱ)配合物,通过红外、X射线单晶衍射对其结构进行了表征。配合物属单斜晶系,P21/n空间群,晶胞参数为a=8.211(5)nm,b=10.419(5)nm,c=21.003(5)nm,β=98.021(5)°,V=1779.2(14)nm3,Z=4。采用紫外光谱和荧光光谱法及循环伏安法研究了配合物与小牛胸腺DNA(ct-DNA)的相互作用。采用MTT法测定了配合物对体外培养人乳腺癌MCF-7和胃癌MGC-803细胞的抑制活性。当配合物浓度为120μmol/L时,对2种细胞增殖的抑制率分别为80.01%和70.16%。

A Cu （ Ⅱ ）-aspirin complex has been synthesized and characterized by IR spectroscopy and single crystal X-ray diffraction analyses. The complex crystallizes in monoelinic space group P21/n with eellparametersof a=8.211（5） nm, b =10.419（5） nm, c=21.003（5） nm, β=98.021（5）°, V = 1779. 2 （14） nm3, Z = 4. The interactions of the complex with ct-DNA were studied by UV, fluorescence spectroscopy and cyclic voltammetry method. At the same time, the antitumor activities of the complex against MCF-7 and MGC-803 cell lines were tested by MTY assay. The in vitro inhibitory ratios against two tumor cell lines are 80. 01% and 70. 16% at concentration of 120 μmol/L, respectively.