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锌指结构基因HKR1在脑胶质瘤中的表达分析 被引量：1

Expression Analysis of Zinc Finger Protein HKR1 in Neuroglioma
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摘要 从人胎脑cDNA文库中筛选到 2 6 12nt的锌指蛋白HKR1克隆 ,C端含有 10个C2 H2 锌指结构 ,N端含有 2个KRAB区域 ,基因芯片和原位杂交检测显示 ,HKR1基因表达在脑胶质瘤中明显升高 ,提示该基因可能是一条潜在的肿瘤相关基因 . The cDNA of HKR1 (Human kruppel related gene 1)has been cloned from a human fetal brain cDNA library with 2 612 nt. It is indicated that HKR1 contains 10 highly conserved C 2H 2 type zinc finger motifs at the C terminus and 2 KRAB(Kruppel associated box)domains at the N terminus. It has been found that the expression of HKR1 is higher in neuroglioma than those in normal brain tissue with cDNA microarray and in situ hybridyzation. The results suggest HKR1 might be a putative cancer associated gene.
作者 夏放 祁震宇 戴建凉 顾少华 马良霄 谢毅 毛裕民
机构地区 复旦大学生命科学学院遗传学研究所 苏州医学院
出处 《复旦学报（自然科学版）》 CAS CSCD 北大核心 2000年第6期692-694,共3页 Journal of Fudan University：Natural Science
基金 上海市现代生物与新药产业发展基金资助项目!(98431912 1)
关键词 锌指蛋白 脑胶质瘤 基因芯片 表达分析 HKR1基因 zinc finger protein neuroglioma microarray
分类号 Q591.2 [生物学—生物化学] R739.41 [医药卫生—肿瘤]
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复旦学报（自然科学版）
2000年 第6期

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