β-arrestin 2在免疫调节中的作用

The role of β-arrestin 2 in immune regulation PENG Ai'ni1, YAN Fuling2,

β-arrestin2是一类arrestin家族成员,它不仅参与调节G蛋白偶联受体(G protein-coupled receptors,GPCRs)的脱敏和内化,还可以作为支架蛋白转导信号通路。目前研究证实,β-arrestin 2可以通过多种途径调节免疫反应,如抑制NF-κB活化、调节趋化因子受体介导的免疫细胞趋化等,同时还参与了多种免疫相关疾病、肿瘤以及炎症的发生和发展。本文就β-arrestin 2在免疫调节中的作用进行综述。

β-arrestin 2 is one member of arrestin family, which not only causes desensitization and internalization of G protein-coupled receptors （GPCRs）, but also serves as a scaffold protein in signal transduction. Now it has been demonstrated that β-arrestin 2 can regulate immune responses through multiple mechanisms, such as inhibiting NF-KB activation and regulating chemokine receptor-mediated cbemotaxis of immune cells. And β- arrestin 2 also participates in the occurrence and development of various immune-related diseases, cancers and inflammation. This paper will elaborate the functions of β-arrestin 2 in regulating immune responses.