SLE伴发干燥综合征患者的临床和免疫学特征分析

Clinical and immunological features of systemic lupus erythematosus patients complicated by secondary Sjgren's syndrome

目的研究干燥综合征(Sj觟gren syndrome,SS)的存在对系统性红斑狼疮(SLE)临床及免疫学特征的影响。方法回顾性分析62例SLE患者(单纯SLE组)和16例SLE伴发干燥综合征患者(SLE+SS组)的病例资料,用统计学方法比较2组在临床表现和免疫学指标上的差异。结果 1)SLE+SS患者的皮肤黏膜损害,如光敏感,口腔溃疡以及雷诺现象和关节炎症较单纯SLE更易发生,而其发生狼疮性肾损害的相对风险较单纯SLE患者反而更低,2组差异显著(P<0.05);2)SLE+SS患者出现相关免疫学标志物的几率与单纯SLE比较:anti-SSB和RF血清水平更高,而anti-dsDNA更低(P<0.05);抗核抗体(ANA),anti-SSA,anti-RNP和anti-Sm,CRP和免疫球蛋白血清水平2组间无显著变化(P>0.05)。结论 SLE伴发SS患者具有独特的临床和免疫学特征,临床应加以重视和区别对待。

In this study, we aimed to investigate the clinical picture and immunological features of patients with secondary Sjogren＇s syndrome （SS） complicated by systemic lupus erythematosus （SLE）. Total of 62 SLE patients and 16 patients met both SLE and SS diagnostic criteria （SLE＋SS） were analyzed retrospectively, while having compared the clinical picture and immunological markers of the two groups by statistical methods. The results showed that the SLE ＋SS patients demonstrated a higher frequency of Raynaud＇s phenomenon, arthritis and mucocutaneous involvement, such as photosensitivity and oral ulcers, as compared with SLE patients without SS; Furthermore, overlap patients showed a lower risk of developing renal damage compared with SLE patients; SLE＋SS patients had a higher frequency of SS-related immunological markers, such as RF and anti-SSB, but a lower positive rate of dsDNA compared with SLE patients without SS. In conclusions, SLE ＋SS patients have distinct clinical and laboratory features different from SLE patients.