摘要
长链非编码RNA(long non-coding RNA,lncRNA)是一类长度大于200核苷酸,缺少特异开放阅读框,不具备蛋白质编码功能的一类RNA分子.在基因组中大量转录的lncRNA,因其在致癌与抑癌途径中显露出的潜在作用,成为继微RNA(microRNA,miRNA)后肿瘤研究的新热点.近年来研究显示,lncRNA参与表观遗传修饰,在基因表达调控中起重要作用,lncRNA与胃癌的发生、发展、肿瘤侵袭、转移密切相关.深入研究lncRNA与胃癌的发病关系有望为胃癌的预防和诊治提供新的策略.本文结合国内外最新报道,对lncRNA在胃癌中的研究进展作一综述.
Long non-coding RNAs （lncRNAs） are a group of RNA molecules which are longer than 200 nucleotides. They do not contain functional open reading frames and can not encode pro- teins. A large number of transcribed lncRNAs in the genome are becoming the new hot spot in cancer research after microRNA due to their carcinogenic and tumor suppressor properties. Recently, several studies indicated that lncRNAs participate in epigenetic modification and play an important role in gene expression regulation. LncRNAs were related to gastric carcinoma de- velopment, invasion and metastasis. Further re- search on the relationship between lncRNAs and gastric carcinoma may provide new strategies for gastric carcinoma prevention, diagnosis and treatment. This article reviews the latest studies on lncRNAs in gastric carcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第4期501-507,共7页
World Chinese Journal of Digestology
关键词
长链非编码RNA
胃癌
研究进展
Long non-coding RNAs
Gastric carci- noma
Research progress
