半乳糖凝集素-9与炎症性肠病关系的研究进展

Galectin-9 and inflammatory bowel disease

半乳糖凝集素-9(galectin-9,Gal-9)是能特异性识别、结合半乳糖苷的半乳糖凝集素家族成员之一.该蛋白广泛表达于机体组织,参与细胞生长、分化、黏附、聚集、凋亡等,与炎症性疾病、自身免疫性疾病、肿瘤、细菌病毒感染等多类疾病密切相关.近年研究发现,G a l-9与炎症性肠病的发生、发展关系密切,本文就Gal-9与炎症性肠病的关系进行综述.

Galectin-9 （Gal-9）, a beta-galactoside binding lectin, is a tandem-repeat-type member of the galectin family which can specifically recog- nize and bind to galactosidase associated with diverse biological processes. Gal-9 is widely expressed in various tissues, plays a role in cell growth, polarization, adhesion, aggregation, andapoptosis, and has important functions in in- flammatory diseases, autoimmune diseases, tu- mors, and infections. Our recent studies showed that Gal-9 is strongly associated with the genesis and development of inflammatory bowel dis- ease. Here we will review the progress in under- standing the role of Gal-9 in the pathogenesis of inflammatory bowel disease.