含丹参复方中丹参酮溶出率对比研究

Extractability of tabshinone in Chinese Medicine prescription which containing Salvia miltiorrhiza Bunge

以活络效灵丹等几种临床常用的含丹参中药复方为模型 ,利用柱色谱 紫外分光光度法对于丹参有效成分丹参酮在不同配伍条件下的溶出率进行了对比研究 .实验结果表明 ,当丹参与泽兰、香附按 4∶3∶2 (重量比 )形成复方时 ,丹参酮的溶出率是纯丹参的 1 7倍 ;与赤芍、乳香、没药、桃仁伍用时 ,溶出率亦成 1 0倍增加 .当丹参与芍药、小茴香以 2∶2∶1形成复方时 ,丹参酮的溶出率仅为纯丹参的 3.9% ,而将其质量比变为 4∶3∶1时 ,丹参酮溶出率会增加至纯丹参的 3.

The content and extractability of tabshinone in liquor of 6 Chinese medicine prescription which containing Salvia miltiorrhiza Bunge have been determined by cylindrical chromatography and ultraviolet spectrophotometry. The results illustrated that the extractability of tabshinone and the effective compositions of Salvia miltiorrhiza Bunge in different prescription can differ 10 times over. That cylindrical chromatography can be used in determining to content of tabshinone be reported first.