脂蛋白相关磷脂酶A2与冠心病的相关性研究进展

Progress of the Correlation Between Lipoprotein Associated Phospholipase A2 and Coronary Heart Disease

脂蛋白相关磷脂酶A2(Lp-PLA2)是由炎性细胞产生并与低密度脂蛋白(LDL)结合,可水解氧化型低密度脂蛋白(ox-LDL)而产生炎症介质促进动脉粥样硬化。Lp-PLA2编码基因PLA2G7的单核苷酸多态性与冠心病之间存在明显相关性。Lp-PLA2作为新型的炎症标记物,与动脉粥样硬化的发生发展密切相关,作为冠心病的一个独立危险因素逐渐被关注,Lp-PLA2可能成为治疗冠心病的新靶点。本文就Lp-PLA2与冠心病的相关性研究新进展进行综述。

Lipoprotein associated phospholipase A2 （Lp-PLA2） is an enzyme produced by irfflammatory ceils and atta-ched to low density lipoprotein （LDL）. Lp-PLA2 hydrolyzes the oxidized LDL and releases inflarranatory meditor to promote atherosclerosis. There is a significant association between the single nucleotide polymorphisms in the PLA2G7 gene and coro nary heart disease. Lp-PIA2 is a novel inflammatory biomarker and has close relationship with the propensity of atherosclero sis. Lp-PLA2 has received attention gradually as an independent risk predictor and may be a new therapeutic target of coronary heart disease. This paper reviewed the recent research in the correlation between Lp-PLA2 and coronary heart disease.