肥胖与乳腺癌关系的研究进展

Progression of relationship between obesity and breast cancer

乳腺癌目前已成为全球女性最常见的恶性肿瘤之一,其发病率和死亡率在女性恶性肿瘤中位居第二。大量临床研究和流行病学资料已证实肥胖与乳腺癌的发生、发展密切相关,其发病机制可能涉及雌激素、胰岛素、胰岛素样生长因子-1(IGF-1)、瘦素、脂联素、炎症因子等多种肥胖相关因子。近年来的研究对肥胖促进乳腺癌发展的机制进行了深入分析,并进一步了解到肥胖对乳腺癌的诊断结果、肿瘤特点、治疗以及预后可产生重要影响。因此,控制体重可能是预防复发转移的积极措施,维持正常体重有助于乳腺癌的防治。

Breast cancer is the second leading cause of death in women and is the most common cancer among women. Large amounts of clinical studies and epidemiological data have confirmed that obesity is closely related to the development and progression of breast cancer, and its pathogenesis is associated with many kinds of obesity related factors, such as estrogen,insulin,insulin-like growth factor-I （IGF-1）, adiponectin, leptin, inflammatory factor and etc. Recently, research on obesity and mechanism to promote the devel- opment of breast cancer has carried on thoroughly; and the important influence of obesity on breast cancer diagnosis, tumor characteris- tics, prognosis and treatment is further understood. Weight control, therefore, may be a positive measure to prevent recurrence and me- tastasis ; maintain a normal body weight can contribute to the prophylaxis of breast cancer.