UbcH10在乳腺浸润性导管癌中的表达及预后分析

Expression of UbcH10 correlates with prognosis of infiltrating ductal carcinoma of breast

目的:探讨UbcH10在乳腺浸润性导管癌中的表达及其与预后的关系。方法:采用免疫组化检测100例乳腺浸润性导管癌组织中UbcH10、ER、PR、Ki-67、p53和HER-2的表达差异,分析UbcH10表达与年龄、TNM分期、分化程度、ER、PR、Ki-67、p53表达及HER-2等特征及预后的相关性。结果:UbcH10在乳腺浸润性导管癌中高表达,在乳腺癌组织与癌旁组织及乳腺良性肿瘤中的表达存在显著差异;UbcH10的表达在不同分化程度之间和乳腺癌各分子分型之间有统计学差异;UbcH10的表达与Ki-67、HER-2表达有相关性;UbcH10的表达与病人年龄、肿块大小、区域淋巴结转移、肿瘤TNM分期、ER、PR、p53表达状态无相关性;UbcH10高表达组预后差,阳性表达的生存时间低于阴性表达。结论:UbcH10在乳腺浸润性导管癌中高表达,预后较差。

Objective To investigate the correlation between the expression of UbcH10 and the prognosis of infiltrating ductal carcinoma of breast. Methods Immunohistochemistry was used to measure the levels of expression of UbcH10, ER, PR, Ki-67, p53 and HER-2 in 100 cases with infiltrating ductal carcinoma of breast and to analyze the correlation between the expression of UbcH10 with the patients＇age, TNM stage, degree of differentiation, and expression of ER, PR, Ki-67, p53 and HER-2. Results The different expression of UbcH10 has statistical difference among the different degree of differentiation in the infiltrating ductal carcinoma of breast and also among the different molecular types of breast cancer. The expression of UbcH10 had correlation with the expression of Ki=67 and HER-2. No difference was present for the expression of UbcH10 with patients＇ age, tumor size, regional lymph node invasion, TNM stage and the expression of ER, PR and p53 in infiltrating ductal carcinoma of breast. The prognosis was worse in the patients with high expression of UbcH10 in infiltrating ductal carcinoma of breast. Conclusions UbcH10 was higher expression in infiltrating ductal carcinoma of breast and the 13rognosis is worse.