摘要
目的:分析趋化因子CXCL14在结直肠癌组织中的表达,并探讨其表达的临床意义。方法:采用实时荧光定量PCR和免疫组化对40例结直肠癌及癌旁正常组织CXCL14的表达进行检测。Kaplan-Meier生存曲线和Cox回归模型评估CXCL14在结直肠癌组织中表达的临床意义。结果:CXCL14 mRNA和蛋白水平在结直肠癌组织中的表达较正常组织明显降低(P<0.05)。临床相关性分析表明,CXCL14表达的下调与肿瘤淋巴结转移、发生部位以及临床病理分期有关(P<0.05)。Kaplan-Meier生存分析显示,不同CXCL14蛋白表达水平的患者,生存时间具有显著差异(P<0.01)。结论:CXCL14可能参与结直肠癌的发生、发展过程。
AIM： To investigate the expression of chemokine CXCL14 and its clinical significance in colorectal cancer. METHODS： The CXCL14 expression was detected by real-time PCR and immunohistochemistry. Kaplan-Meier curve and Cox regression were used to evaluate the clinical significance of CXCL14 in colorectal cancer. RESULTS： The expression of CXCL14 at mRNA and protein levels declined in colorectal cancer tissues compared with the paired normal tissues （P 〈 0.05）. Down-regulation of CXCL14 was associated with tumor lymph node metastasis, the site and the clinical pathological stage （P 〈 0.05 ）, and also correlated with the prognosis closely. Kaplan-Meier survival analysis showed that the protein expression levels of CXCL14 were significantly different in the patients with different survival time （P 〈0.01 ）. CONCLUSION： It is possible that CXCL14 acts a role in the development and progression of colorectal cancer.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2014年第2期355-358,373,共5页
Chinese Journal of Pathophysiology
基金
浙江省科技厅公益性技术应用研究计划项目(No.2012C37080)
浙江省教育厅项目(No.Y201327980)
