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急性冠脉综合征患者血清高敏C反应蛋白、髓过氧化物酶变化的临床意义 被引量：6

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摘要 目的探讨急性冠脉综合征(ACS)患者血清高敏C反应蛋白(hs-CRP)及髓过氧化物酶(MPO)变化的临床意义。方法选择ACS患者110例,其中急性心肌梗死(AMI)50例,不稳定型心绞痛(UAP)60例,另选40例稳定型心绞痛(AP)患者作为对照组。检测3组入院后的外周静脉血及冠状动脉血血清hs-CRP、MPO,并分析ACS患者血清hs-CRP与MPO水平的相关性。结果 UAP、AMI患者的血清hs-CRP、MPO高于对照组,AMI患者高于UAP患者(P均<0.05);ACS患者的外周静脉血、冠状动脉血血清hs-CRP与MPO水平呈正相关(r分别为0.286、0.255,P均<0.05)。结论血清hs-CRP、MPO升高与ACS发生有密切关系,hs-CRP、MPO是ACS(特别是AMI)发生的预测指标,二者联合检测有助于对ACS进行危险分层。
作者 郝永 高蕊 代建军 张晓春
机构地区 济宁医学院附属金乡医院
出处 《山东医药》 CAS 2014年第5期47-48,共2页 Shandong Medical Journal
关键词 急性冠脉综合征 C反应蛋白质 髓过氧化物酶 炎症反应
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献12

  • 1KKaya MG, Yalcin R, Okyay K, et al. Potential role of plasma my- eIoperoxidase level in predicting long-term outcome of acute myo- cardial infarction[ J1. Tex Heart Inst J, 2012,39(4) :500-506.
  • 2岳霞,吴华,陈新山.炎症与急性冠状动脉综合征的研究进展[J].临床心血管病杂志,2005,21(6):378-380. 被引量：11
  • 3Monaco C, Paleolog E. Nuclear factor kappaB : a potential therapeu- tic target in atherosclerosis and thrombosis [J]. Cardiovasc Res, 2004,61(4) :671- 682.
  • 4Jneid H. The 2012 ACCF/AHA focused update of the unstable angi- na/non-ST-elevation myocardial iniarction ( UA/NSTE-MI ) guide- line: a critical appraisal [ J]. Methodist Debakey Cardiovasc J, 2012,8(3 ) :26-30.
  • 5侯振林,宋超,陶婧雯.Cav-1对动脉粥样硬化斑块的促进与抑制作用[J].山东医药,2013,53(9):89-91. 被引量：2
  • 6Yayan J. Emerging families of biomarkers for coronary artery dis- ease: inflammatory mediators [ J ]. Vasc Health Risk Manag, 2013, (9) :435-456.
  • 7Koenig W. High-sensitlvity C-reactive protein and atherosclerotic disease: from improved riskprediction to risk-guided therapy[ J ]. Int J Cardiol, 2013,7(13) : 1324-1327.
  • 8Lrpez A, Manzano S, Lip GY, et al. Interleukin-6 and high-sensi- tivity C-reactive protein for the prediction of outcomes in non-ST- segment elevation acute coronary syndromes[ J]. Rev Esp Cardiol, 2013,66(3) :185-192.
  • 9Hong YJ, Jeong MH, Choi YH, et al. Relation between high-sen- sitivity C-reactive protein and coronary plaque components in pa- tients with acute coronary syndrome: virtual histology-intravascular ultrasound analysis [ J ]. Korean Circ J, 2011,41 ( 8 ) :440 -446.
  • 10Anatoliotakis N, Deftereos S, Bouras G. et al. Myeloperoxidase: expressing inflammation and oxidative stress in cardiovascular dis- ease[J]. Curt Top Med Chem, 2013,13(2):115-138.

二级参考文献40

  • 1卢桂静,刘文龙,李方雄,张国刚,杨天伦,Berglund L.冠心病稳定性心绞痛患者血浆髓过氧化物酶的变化[J].中华老年医学杂志,2006,25(11):829-831. 被引量：11
  • 2张京梅,李十红,李志忠,卢辛,邢雁伟,王阶.髓过氧化物酶和肌钙蛋白Ⅰ与急性冠状动脉综合征[J].中华内科杂志,2007,46(6):496-497. 被引量：1
  • 3严松彪,苏淑红,陈晖,韩炜,高红丽,梁思文,李虹伟,王雷,贾三庆.血浆髓过氧化物酶水平对急性心肌梗死患者预后的影响[J].实用医学杂志,2007,23(13):2000-2002. 被引量：5
  • 4Sugiyama S,Kugiyama K,Aikawa M,et al.Hypochlorous acid,a macrophage product,induces endothelial apoptosis and tissue factor expression:involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis[J].Arterioscler Thromb Vasc Biol,2004,24(7):1309-1314.
  • 5Morrow D A,Sabatibe M S,Brennan M L,et al.Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome:myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18[J].Eur Heart J,2008,29(9):1096-1102.
  • 6Cavusoglu E,Ruwende C,Eng C,et al.Usefulness of baseline plasma myeloperoxidase levels as an independent predictor of myocardial infarction at two years in patients presenting with acute coronary syndrome[J].Am J Cardiol,2007,99(10):1364-1368.
  • 7Brennan M L,Penn M S,Van Lente F,et al.Prognostic value of myeloperoxidase in patients with chest pain[J].N Engl J Med,2003,349(17):1595-1604.
  • 8Esporcatte R,Rey H C V,Rangel F O J,et al.Predictive value of myeloperoxidase to identify high risk patients admitted to the hospital with acute chest pain[J].Arq Bras Cardiol,2007,89(6):377-384.
  • 9Mocatta T J,Pilbrow A P,Cameron V A,et al.Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction[J].J Am Coll Cardiol,2007,49(20):1993-2000.
  • 10Dominguez-Rodriguez A,Samimi-Fard S,Abreu-Gonzalez P,et al.Prognostic value of admission myeloperoxidase levels in patients with ST-segment elevation myocardial infarction and cardiogenic shock[J].Am J Cardiol,2008,101(11):1537-1540.

共引文献12

同被引文献61

  • 1钱卫东.中医药对急性冠状动脉综合征炎症反应干预的研究[J].河南中医学院学报,2005,20(4):83-84. 被引量：11
  • 2刘华宝,杜志林.中西医结合治疗冠心病心绞痛43例[J].四川中医,2005,23(10):62-62. 被引量：2
  • 3唐照亮,宋小鸽,刘先华,陈全珠,王宁新,侯正明.针刺对失血性休克家兔体液因素的影响[J].安徽中医学院学报,2006,25(2):15-17. 被引量：7
  • 4徐萍,徐东升,陈江,吕农华,王崇文.髓过氧化物酶对炎症性肠病病情活动监测的临床价值[J].江西医药,2006,41(10):732-734. 被引量：4
  • 5骆抗先.乙型肝炎基础和临床[M]第2版[M].北京：人民卫生出版社,2001.43-70.
  • 6Leoncini M,Toso A,Maioli M,et al.Early high-dose rosuvastatin and cardioprotection in the protective effect of rosuvastatin and antiplatelet therapy on contrast-induced acute kidney injury and myocardial damage in patients with acute coronary syndrome (PRATO-ACS) study[J].Am Heart J,2014,168(5):792-797.
  • 7Sexton TR,Wallace EL,Macaulay TE,et al.The effect of rosuvastatin on thromboinflammation in the setting of acute coronary syndrome[J].J Thromb Thrombolysis,2014,12(12):1-6.
  • 8Gurumurthy P,Borra SK,Yeruva RK,et al.Estimation of ischemia modified albumin (IMA) levels in patients with acute coronary syndrome[J].Indian J Clin Biochem,2014,29(3):367-371.
  • 9Koch C,Henrich M,Heidt MC.Sequential analysis of myeloperoxidase for prediction of adverse events after suspected acute coronary ischemia[J].Clin Cardiol,2014,17(11):247-254.
  • 10慢性乙型肝炎抗病毒治疗々家委员会.慢性乙型肝炎抗病毒治疗々家共识[J].中华实验和临床感染病杂志:电子版,2010,4(1):82-91.

引证文献6

二级引证文献8

山东医药
2014年 第5期

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