蒙特卡洛联合生理模型在兽药残留研究中的应用
被引量：3
摘要
目前，食品安全已成为全球日益关注的焦点，兽药残留是影响食品安全的主要因素之一。动物可食性产品中兽药残留受动物种属、药物种类、制剂类型、用药剂量、给药途径及生理状况等因素影响。传统的组织残留消除研究，是在自然生产的条件下给动物暴露化合物后（如饲喂、注射给药），在一系列时间随机抽样宰杀动物，测定组织中残留物（原形或代谢产物）的量，用分布容积、消除半衰期、清除率等参数阐明药物在体内的分布和消除规律。每个动物在每个时间点只有一个样本，所用动物数量有限，以致数据结果差异大、零乱、难处理，影响残留预测的准确性。
出处
《中国兽医杂志》
CAS
北大核心
2014年第1期57-59,共3页
Chinese Journal of Veterinary Medicine
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