转移因子口服液辅助治疗反复呼吸道感染老年患者疗效观察

Curative Effect Observation of Transfer Factor Oral Solutions as Adjunctive Therapy in Elderly Patients with Recurrent Respiratory Tract Infection( RRTI)

目的:观察转移因子口服液对老年反复呼吸道感染患者体液免疫功能的影响及疗效。方法:老年反复呼吸道感染患者74例随机分为观察组与对照组。两组患者急性发作期均予抗感染及对症治疗,观察组患者在此基础上加用转移因子口服液10 ml,po,tid,连用3个月。比较两组患者治疗前后血清免疫球蛋白IgG、IgA和IgM水平的变化、临床疗效及药品不良反应。结果:观察组患者血清IgG、IgA和IgM水平较治疗前明显上升(P<0.05),而对照组治疗前后血清IgG、IgA和IgM水平无明显变化(P>0.05);观察组总有效率显著高于对照组(P<0.01),两组患者药品不良反应比较,差异无统计学意义(P>0.05)。结论:转移因子口服液辅助治疗反复呼吸道感染具有较好的临床疗效及安全性,与其提高血清免疫球蛋白IgG、IgA和IgM水平,增强机体的体液免疫功能密切相关。

Objective： To observe the curative effect of transfer factor oral solutions as the adjunctive therapy in ederly patients with recurrent respiratory tract infection （RRTI）. Methods： Totally 74 ederly patients with RRTI were selected and divided into the observation group and the control group randomly. The patients in the two groups were given anti-infection and symptomatic treatment during the acute stage of attack. The patients in the observation group were additionally given transfer factor oral solutions 10ml, po, tid for 3 months. The changes in serum immunoglobulin IgG, IgA and IgM levels in the two groups before and after the medical treatment were compared, and the clinical curative effect and adverse drug reactions （ADR） were observed as well. Results：After the medical treatment, the serum IgG, IgA and IgM levels in the observation group were obviously increased than before （P〈0.05）, while those in the control group showed no obvious changes （P〉0.05）. The total clinical efficiency in the observation group was much higher than that in the control group （P〈0.01）. The ADR between the two groups with light symptoms showed no statistical differences （P〉0.05）. Conclusion：Transfer factor oral solutions as the adjunctive therapy in ederly patients with RRTI has the favorable clinical curative effect and safety, and the underlying mechanisms may be concerned with the effect of enhancing serum immunoglobulin IgG, IgA and IgM levels, as well as humoral immune function.