阻塞型睡眠呼吸暂停低通气综合征患者C-反应蛋白与尿微量白蛋白的相关性分析

Correlation Analysis between C-reactive Protein and Microalbuminuria among Adult Obstructive Sleep Apnea-hypopnea Syndrome Patients

目的深入探讨阻塞型睡眠呼吸暂停低通气综合征(OSAHS)患者C-反应蛋白(CRP)与尿微量白蛋白(UMA)之间的相关性。方法应用散射比浊法测定29例OSAHS合并尿微量白蛋白患者(OSAHS+UMA组),30例单纯OSAHS患者(OSAHS组)和28例健康志愿者(正常对照组)血清中C反应蛋白(CPR)含量。结果 OSAHS+UMA组和单纯OSAHS组血清中CPR高于正常对照组(P<0.05);OSAHS+UMA组CPR亦高于OSAHS组(P<0.05)。OSAHS患者血清CPR水平与睡眠呼吸暂停低通气指数(AHI)、血尿微量白蛋白水平存在正相关(P<0.05)。结论血清CRP的增高是OSAHS患者发生尿微量白蛋白及肾脏损伤的重要危险因子和预测因子之一。

Objectives To investigate the relationship between c-reactive protein （ CPR ） and microalbuminuria （ UMA ） among adult obstructive sleep apnea-hypopnea syndrome （ OSAHA ） patients. Methods To measure the content of CPR in serum with scattering turbidimetry method in the three groups, which were OSAHA plus UMA group with 29 cases of patients, OSAHS only group with 30 cases of patients and health control group with 30 cases of volunteers. Results The serum CRP in OSAHA plus UMA group and SAHS only group were significantly higher than that in health control group （ P〈O.05 ）, and serum CRP in OSAHA plus UMA group higher than that in group SAHS only （ P〈0.05 ） . The serum CRP level in OSAI-IA patients were correlated positively with apnea hypopnea index （ AHI ） and UMA level （ P〈0.05 ）. Conclusions The increase of serum CRP is one of the important risk factors as well as predictive factors for the incidence of microalbuminuria and kidney damage among OSAHS patients.