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寻找阿尔茨海默病的易患基因 被引量：4

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摘要 阿尔茨海默病（Alzheimer＇s disease,AD）是一种以进行性认知功能障碍和行为损害为特征的中枢神经系统退行性病变,是老年期痴呆的最常见类型.然而其确切病因及发病机制尚不清楚.目前认为,AD是一种由环境和遗传因素共同作用的多基因病.AD可分为家族性AD（或称为早发性AD,early-onset？AD, EOAD）和散发性AD（或称为迟发性AD,late-onset AD, LOAD）[1].早期研究显示,β-淀粉样前体蛋白（APP）基因、早老素-1基因、早老素-2基因为EOAD的主要致病基因,而载脂蛋白E（ApoE）基因是近20年来唯一公认的LOAD易患基因.
作者 王俊 郁金泰 谭兰
机构地区 青岛大学医学院附属青岛市立医院神经内科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2014年第2期128-132,共5页 Chinese Journal of Neurology
基金 国家自然科学基金资助项目（81000544,81171209,81371406） 山东省自然科学基金资助项目（ZR2010HQ004,ZR2011HZ001）
关键词 易患基因 阿尔茨海默病 早老素-1基因 Β-淀粉样前体蛋白 家族性AD 中枢神经系统 认知功能障碍 退行性病变
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献43

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二级参考文献54

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共引文献9

同被引文献49

  • 1刘兴彦,尹利德,段勇,王玉明,程宝文,王燕.家族性阿尔茨海默病早老素-1基因突变研究[J].中华医学遗传学杂志,2004,21(5):455-458. 被引量：4
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中华神经科杂志
2014年 第2期

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