载紫杉醇共聚物胶束的合成与表征

Preparation and Characterization of Paclitaxel-loaded Polymeric Micelles

目的:制备一种包封率、载药量高的紫杉醇载体材料。方法:开环聚合法一步合成了两种两亲性共聚物PTL1和PTL2,以核磁和凝胶渗透色谱进行了产物的表征,以固体分散-超声法制备紫杉醇胶束,考察了胶束的载药量、包封率。结果:核磁和凝胶渗透色谱的结果显示得到了目标产物,所制备得到的载紫杉醇胶束包封率可以达到90%以上,载药量为9.5%以上。结论:实验结果表明我们所合成的PTL1和PTL2是好的紫杉醇载体材料。

Objective： To obtain a high loading and encapsulation efficiency micellar cartier of paclitaxel. Methods： Amphiphilic block copolymers PTL1 and PTL2, were synthesized by ring-opening polymerization and their compositon were characterized by 1H-NMR and GPC. Paclitaxel micelles were prepared through solid-dispersion-sonication method. The drug loading and encapsulation efficiency of the micelles were investigated. Results： PTL1 and PTL2 were successfully synthesized The drug loading contents of micelles were higher than 9.5% and the encapsulation efficiency were high than 90%. Conclusion： PTL1 and PTL2 could be promising paclitaxel micellar carders.