Bcl-2和COX-2在宫颈鳞癌中的表达及其临床意义

The Expression and Clinical Significance of Bcl-2 and COX-2 in Cervical Squamous Cell Cancer

目的:观察Bcl-2和COX-2在正常宫颈和宫颈鳞癌中的表达情况,并探讨其与宫颈鳞癌发生发展的关系。方法:应用免疫组织化学S-P法检测40例宫颈鳞癌组织、10例正常宫颈组织中Bcl-2和COX-2的表达情况。结果:(1)Bcl-2在正常宫颈组织和宫颈鳞癌组织中的阳性表达率分别为30.0%、72.5%(P<0.05),而COX-2在正常宫颈组织和宫颈鳞癌组织中的阳性表达率分别为0.0%、60.0%(P<0.05)。(2)在宫颈鳞癌中,Bcl-2的表达与宫颈鳞癌的病理分级、临床分期以及淋巴结转移无关(P>0.05),而COX-2的表达与宫颈鳞癌的病理分级及淋巴转移有关(P<0.05),与临床分期无关(P>0.05)。(3)Spearman等级相关性分析显示宫颈鳞癌组织中Bcl-2和COX-2的表达呈正相关(r=0.517,P<0.01)。结论:Bcl-2和COX-2在宫颈鳞癌中的表达升高并呈显著正相关,且COX-2的表达与宫颈鳞癌的淋巴转移有关,二者在宫颈癌的发生发展中可能起重要作用,有可能作为评估宫颈鳞癌淋巴结转移的参考指标。

Objective： To detect the expression of Bcl-2 and COX-2 in cervical squamous cell cancer and explore the clinical significance of Bcl-2 and COX-2 in the development of cervical squamous cell cancer. Methods： The expression of Bcl-2 and COX-2 in 40 cases of cervical squamous cell cancer and 10 cases of normal cervical tissue were detected by imrnunohistochemical SP method. Results： （1）The positive expression rates of Bcl-2 in normal cervical tissue and cervical squamous cell cancer were 30.0 % and 72.5%, respectively （P〈0.05）.The positive expression rates of COX-2 in normal cervical tissue and cervical squamous cell cancer were 0.0% and 60.0%, respectively（P〈0.05）. （2）The expression of Bcl-2 in cervical squamous cell cancer was not related with the histological grade, the clinical stage and the lymph node metastasis （P〉0.05）, while the expression of COX-2 in cervical squamous cell cancer was related with the histological grade and the lymph node metastasis（P〈0.05）, but not related to the clinical stage（P 〉0.05）. （3）The expression of Bcl-2 was positively correlated with the expression of COX-2 （r =0.517, P〈0.05）. Conclusion： The upregulation of Bcl-2 and COX-2 expression which were positively related were involved in the development of cervical squamous cell cancer, they may be used as indicators of the prognosis of cervical squamous cell cancer.