摘要
目的:观察Bcl-2和COX-2在正常宫颈和宫颈鳞癌中的表达情况,并探讨其与宫颈鳞癌发生发展的关系。方法:应用免疫组织化学S-P法检测40例宫颈鳞癌组织、10例正常宫颈组织中Bcl-2和COX-2的表达情况。结果:(1)Bcl-2在正常宫颈组织和宫颈鳞癌组织中的阳性表达率分别为30.0%、72.5%(P<0.05),而COX-2在正常宫颈组织和宫颈鳞癌组织中的阳性表达率分别为0.0%、60.0%(P<0.05)。(2)在宫颈鳞癌中,Bcl-2的表达与宫颈鳞癌的病理分级、临床分期以及淋巴结转移无关(P>0.05),而COX-2的表达与宫颈鳞癌的病理分级及淋巴转移有关(P<0.05),与临床分期无关(P>0.05)。(3)Spearman等级相关性分析显示宫颈鳞癌组织中Bcl-2和COX-2的表达呈正相关(r=0.517,P<0.01)。结论:Bcl-2和COX-2在宫颈鳞癌中的表达升高并呈显著正相关,且COX-2的表达与宫颈鳞癌的淋巴转移有关,二者在宫颈癌的发生发展中可能起重要作用,有可能作为评估宫颈鳞癌淋巴结转移的参考指标。
Objective: To detect the expression of Bcl-2 and COX-2 in cervical squamous cell cancer and explore the clinical significance of Bcl-2 and COX-2 in the development of cervical squamous cell cancer. Methods: The expression of Bcl-2 and COX-2 in 40 cases of cervical squamous cell cancer and 10 cases of normal cervical tissue were detected by imrnunohistochemical SP method. Results: (1)The positive expression rates of Bcl-2 in normal cervical tissue and cervical squamous cell cancer were 30.0 % and 72.5%, respectively (P〈0.05).The positive expression rates of COX-2 in normal cervical tissue and cervical squamous cell cancer were 0.0% and 60.0%, respectively(P〈0.05). (2)The expression of Bcl-2 in cervical squamous cell cancer was not related with the histological grade, the clinical stage and the lymph node metastasis (P〉0.05), while the expression of COX-2 in cervical squamous cell cancer was related with the histological grade and the lymph node metastasis(P〈0.05), but not related to the clinical stage(P 〉0.05). (3)The expression of Bcl-2 was positively correlated with the expression of COX-2 (r =0.517, P〈0.05). Conclusion: The upregulation of Bcl-2 and COX-2 expression which were positively related were involved in the development of cervical squamous cell cancer, they may be used as indicators of the prognosis of cervical squamous cell cancer.
出处
《现代生物医学进展》
CAS
2014年第3期486-489,共4页
Progress in Modern Biomedicine
关键词
BCL-2
COX-2
宫颈鳞癌
表达
临床意义
Bcl-2
COX-2
Cervical squamous cell cancer
Expression
Clinical significance