选择性5-羟色胺再摄取抑制剂的临床应用进展

Clinical Application Progress of SSRIs

5-羟色胺(5-hydroxy tryptamine,5-HT)是中枢及外周神经系统中一种重要的神经递质。5-羟色胺转运体(5-HT transporter,5-HTT)可将5-HT再摄取,降低细胞外5-HT浓度,从而调节神经信号传导。5-HTT异常在某些精神疾病的发病中起重要作用。近年来选择性5-羟色胺再摄取抑制剂(selective serotonin reuptake inhibitors,SSRIs)在临床上的应用日趋广泛,如治疗抑郁症、焦虑症、抑郁和焦虑共病等常见的精神疾病。氟西汀、帕罗西汀、舍曲林、氟伏沙明和西酞普兰是目前临床上最常用的五种SSRIs,被誉为抗抑郁药的"五朵金花"。本文详细介绍近年来在临床上药物治疗抑郁症取得的成果以及这类药物的药效学、药动学、不良反应和相互作用等,并简要介绍SSRIs在其它疾病领域取得的应用进展。

： 5-HT is an important neurotransmitter in the central and peripheral nervous system. 5-HTT can reuptake 5-HT and reduce its extracellular concentration. Researchers have found that 5-HT anomaly playsan important role in the etiologies of some mental illnesses. The clinical applications of SSR/s have been increasingly widespread these years, such as depression, anxiety disorder, panic disorder, etc. Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, Citalopram are the most popular medicines against depression. This article introduces the achievements of SSRIsand their pharmacodynarnics, pharmacokinetics, side effects and interactions. The progress of the treatments of other diseasesusing SSRIs is also included.