Livin蛋白在非小细胞肺癌中的表达及其临床意义

Expression of Livin in Non-small Cell Lung Cancer and its Clinical Significance

目的:研究livin蛋白在非小细胞肺癌中的表达及其与非小细胞肺癌的生物学特性及临床预后的关系。方法:通过免疫组化的方法检测和比较88例非小细胞肺癌组织和20例癌旁正常肺组织中livin蛋白的表达,并分析其与非小细胞肺癌的临床病理特征和预后的相关性。结果:非小细胞肺癌组织及癌旁正常肺组织中livin蛋白的阳性表达率分别为54.55%和5%,差异有显著统计学差异(P<0.05)。非小细胞肺癌组织中livin蛋白的表达水平与淋巴结转移、TNM分期显著相关(P<0.05),但与患者的性别、年龄、分化程度及病理学类型无关(P>0.05)。Livin高表达的非小细胞肺癌患者生存时间显著短于livin低表达的患者(P<0.05)。结论:Livin蛋白在非小细胞肺癌的发生及发展中起重要作用并与患者的预后相关,可能作为非小细胞肺癌新的防治靶点。

Objective： To study the expression of livin in non-small cell lung cancer and its clinical significance. Methods： The liv- in protein expression in 88 cases of NSCLC tissue samples and 20 cases of normal lung tissue samples were detected through immunohistochemistry. Results： The positive expression rate of livin protein in NSCLC tissues and normal tissues were respectively 54.55 % and 5 %. Which was significantly higher in NSCLC tissues （P〈0.05）. The protein expression of livin was significantly related with the lymph node metastasis, TNM stage, but it was unrelated with sex, age and differentiation degree and pathological type of NSCLC. The survival time in livin high expression group was significantly Shorter than that in the livin low expression group. Conclusion： Livin protein had important role in the occurrence and development of NSCLC and was related with its prognosis, which would become a new therapeutic targets of NSCLC.