MACC1蛋白在食管癌中的表达及其临床意义

Expression of MACC1 in Esophageal Cancer and its Clinic Significance

目的:探讨结肠癌转移相关基因1(metastasis-associated in colon cancer-1,MACC1)在食管癌组织中的表达及其临床意义。方法:采用免疫组化EnVinsion法检测MACC1蛋白在88例食管癌组织中的表达,统计学分析MACC1蛋白在不同病理分级、TNM分期中表达的差异性。结果:免疫组化结果显示MACC1蛋白的阳性表达主要位于胞浆中。MACC1蛋白在食管癌组织中的总阳性率为88.64%;在I、II、III级食管癌组织中的阳性率分别为14.29%、93.65%、100%,经Kruskal-Wallis H检验差异性非常显著(P=0.0000);在I、IIa、IIb、III期食管癌中的阳性率分别是16.67%、89.47%、100%、100%,经Kruskal-Wallis H检验差异性非常显著(P=0.0000)。结论:MACC1蛋白在食管癌中呈过度表达,其表达与病理分级、TNM分期相关,提示MACC1可能在食管癌的发生、发展中起重要作用。MACC1蛋白可能成为检测食管癌的发病及判断预后的生物学指标之一。

Objective： To investigate the expression of MACC1 in esophageal cancer and analyze its clinical significance, Methods： The expression of MACC1 protein in 88 samples of esophageal cancer tissues was detected with immunohistochemical method-EnVision method; the differences of the protein expression among different pathological grades and TNM stages were statistically analyzed. Results： The positive expression of MACC1 protein was mainly located in the cytoplasm indicated by immunohistochemical method. The total positive rate of MACC1 protein in esophageal cancer was 88.64%; the positive expression rates of pathological gradingI, II, III in esophageal cancer tissues were 14.29%, 93.65%, 100% respectively with extremely significant difference （Kruskal-Wallis H test, P=0.0000）; the positive expression rates of TNM stageI, IIa, lib, Illesophageal cancer tissues were 16.67%, 89.47%, 100%, 100% respectively with extremely significant difference （Kruskal-Wallis H test, P=0.0000）. Conclusions： MACC1 protein is overexpressed in esophageal cancer and its expression rate is related with pathological grading and TNM stage, which suggests MACC1 might play an important role in the development of esophageal cancer. MACC1 protein may be one of biological indicators for diagnosis and prognosis of esophageal cancer.