Gankyrin与消化系统肿瘤关系的研究进展

Research Progress of the Relationship between Gankyrin and Digestive System Neoplasms

消化系统肿瘤与多种肿瘤相关基因的异常表达密切相关,Gankyrin是一种癌基因,于肝癌、结直肠癌、胰腺癌等消化系统肿瘤中高表达,并通过依赖泛素的蛋白酶解系统介导多种转录因子、细胞周期调控蛋白以及抑癌蛋白如p53、Rb等的降解。研究表明,Gankyrin在消化系统肿瘤形成及细胞的生长周期调控中发挥重要作用,在消化系统肿瘤的早期诊断及判断预后方面具有一定的应用前景,同时也可能成为消化系统肿瘤基因治疗的潜在靶点。

： The digestive system neoplasms are associated with abnormal expression of multiple tumor related genes. Gankyrin is an oncogene, which has been found to have high expression in the digestive system neoplasms such as hepatocellular carcinoma, colorectal cancer, pancreatic cancer, etc. It mediates the degradation of a variety of transcrpfion factors, cell cycle regulation proteins and tumor suppressor proteins including p53, Rb, etc, by the protease solution system that relies on ubiquitin. Study proves that Gankyrin plays an important role in tumorigenesis and cell cycle control of digestive system neoplasms. It has certain application prospect in the early diagnosis and prognosis of digestive system neoplasms and may become a promising target for therapy.