胆囊结石合并急性胰腺炎患者早期腹腔镜胆囊切除术的临床疗效

Clinical effects of early laparoscopic cholecystectomy for the patients with acute pancreatitis with gallbladder stone

目的 探讨胆囊结石合并轻中度胰腺炎患者实施早期腹腔镜胆囊切除术（LC）的可行性及手术时机.方法 将26例确诊后经保守治疗病情平稳、发病48 h内行LC术轻中度胆囊结石伴胰腺炎的患者列为早期LC组,与58例延期手术组的临床资料作对照研究.结果 所有LC手术成功.早期手术组术后第1、3、5、7天的丙氨酸转氨酶＋天冬氨酸转氨酶、血尿淀粉酶、碱性磷酸酶与延期手术组入院治疗第1、3、5、7天比较,差异无统计学意义（P＞0.05）.早期手术组住院日明显缩短（P＜0.05）.两组手术时间、术中出血量、术后并发症发生率、术后胰腺炎复发率差异均无统计学意义（P＞0.05）.结论 明确排除胆总管结石后,胆囊结石合并轻中度胰腺炎在发病48 h内行早期LC是安全可行的.

Objective To study the feasibility and timing of early laparoscopic cholecystectomy （LC） for the patients with mild-to-moderate acute pancreatitis with gallbladder stone.Methods 26 patients with mild-to-moderate acute pancreatitis with gallbladder stone underwent early laparoscopic cholecystectomy.The patients were initially treated with conservative treatment.When the diagnosis was confirmed and the patients were stable,LC was carried out within 48 hours of hospitalization.The results were compared with a delayed group of patients who received delayed LC for acute pancreatitis.Results All the LC operations were successfully carried out.There were no significant differences between the two groups in alkaline phosphatase,alanine aminotransferase,aspartate aminotransferase,blood amylase and urine armylase on postoperative day 1,3,5,7.Patients who received early laparoscopic cholecystectomy had a shorter hospital stay.There were no significant differences between the two groups in the operation time,intraoperative blood loss,postoperative complication rates and recurrence of acute pancreatifis.Conclusion After CBD stones have been ruled out,it is safe and feasible to carry out early laparoscopic cholecystectomy within 48 hours of hospital admission for patients with mild-to-moderate acute pancreatitis with gallbladder stone.