健康人群血浆8-羟基脱氧鸟苷水平及其影响因素

Plasma level and influencing factors of 8-hydroxy-2′-deoxyguanosine in healthy population

目的探讨健康人群血浆8-羟基脱氧鸟苷(8-OHdG)水平及其影响因素。方法用ELISA法检测江苏阜宁县319例50岁以上健康人血浆8-OHdG水平,分析年龄、性别、吸烟、饮酒、日照因素对血浆8-OHdG水平的影响。结果319例健康人血浆8-OHdG水平为(219.27±104.40)pg/ml。血浆8-OHdG水平与年龄呈正相关(P<0.01)。年龄大、日照时间长的男性血浆8-OHdG水平较高(P<0.05)。结论年龄和日照时间可能是影响健康人群氧化应激水平的主要因素。

Objective To investigate plasma level and influencing factors of 8-hydroxy-2＇- deoxyguanosine（8-OHdG） in healthy people aged over 50 years old in Funing Country, Jiangsu province. Methods Plasma concentrations of 8-OHdG in 319 healthy people were determined by ELISA. The effects of age, gender, smoking, drinking and sunlight time on 8-OHdG were analyzed. Results Plasma concentration of 8-OHdG in 319 healthy people was （219.27±104. 40） pg/ml,which was positively correlated to age（P〈0. 01）. Plasma level of 8-OHdG was significantly increased in elder males with more sunlight time （P〈0. 05 ）. Conclusion The age and sunlight time are the important factors to influence the oxidative stress in healthy populatiorL