进展期白癜风患者治疗前后血清免疫球蛋白和补体的检测分析

The Detection and Analysis on Serum Immunoglobulins and Complement Levels of Vitiligo Patients

目的探讨白癜风患者治疗前后血清免疫球蛋白和补体水平及临床意义。方法采用免疫散射比浊法检测67例进展期白癜风患者治疗前后血清免疫球蛋白IgG,IgA,IgM和补体C3,C4水平,根据不同分型分为节段型和非节段型,并以50例正常人作为对照组进行对比。结果白癜风患者治疗前与健康对照组相比C3水平降低,差异有统计学意义(P<0.01);IgG,IgA,IgM,C4与对照组比较,差异无统计学意义(P>0.05)。节段型与非节段型白癜风患者血清IgG,IgA,IgM,C3和C4水平比较,差异无统计学意义(P>0.05)。白癜风患者治疗后C3水平高于治疗前(P<0.01),接近正常水平。结论白癜风患者血清免疫球蛋白和补体水平存在异常,通过治疗可以进行调节。

Objective To detect serum levels of immunoglobulins and complements in patients with vitiligo and evalu- ate its clinical significance. Methods Immunoturbidimetry was adopted to detect serum levels of IgG,IgA, IgM, C3, and C4 of 67 patients with developing vitiligo before and after treatment. 67 vitiligo patients were di- vided into divided into two groups according to their subtypes such as segmental and non-segmental. The re- suits were compared to those of 50 healthy individuals. Results The serum C3 in vitiligo patients was signif- icantly reduced than that in healthy cases（ P 〈 0.01 ）. compared to controls, the serum levels of IgG, IgA, IgM and C4 were of no significant difference（P 〉0.05）. It was observed that The serum levels of IgG,lgA,IgM, C3 and C4 were also of no significant difference between segmental and non-segmental vitiligo patients（ P 〉 0.05 ）. After treatment, the serum C3 level in vitiligo patients was significantly increased （P 〈 0.01 ） , close to normal serum levels. Conclusion The serum immunoglobulin and complement levels of vitiligo patients are abnormal, which can be corrected to normal levels by means of treatments.