硬组织植入多孔钛的制备及其性能研究

Preparation and Characterization of Porous Titanium Scaffolds as Hard Tissue Substitute

为满足硬组织植入多孔材料的需求，在传统粉末烧结法的基础上，利用造粒-松装烧结法制备了多孔钛．比较了这两种方法制备出的多孔钛性能和结构差异。结果表明：粉末烧结法制备的多孔钛样品为均一型孔结构且孔隙度较低，同时过高的力学性能限制了该方法的应用；采用造粒一松装烧结法制备出的多孔钛孔隙度为60％-80％，同时多孔钛的孔结构为大孔孔壁分布着均匀微米级小孔的双峰孔结构，力学性能与人体骨组织较好匹配，完全符合硬组织植入体的性能要求。

In order to meet the requirements of hard tissue substitute,the Granulating Loose Pack Sintering Method （GLPS） was used to fabricate porous titanium scaffolds in the base of traditional Loose Pack Sintering method （LPS）, and was expected to obtain a more biocompatible titanium scaffolds with bimodal porous structure. The results show that the porous titanium scaffolds prepared by LPS has a lower porosity and a single single-sized porous structure, however, the porous titanium scaffolds with a porosity ranges fi＇om 60% to 80% were successfully fabricated using granulating loose pack sintering method, which mainly contains two types of pores： macro-pores between the granules and micro-pores on and inside of the cell walls. Furthermore, the results of mechanical property and chemistry composition show that the scaffold can completely satisfy the requirement of hard tissue substitute.