血清成纤维细胞生长因子-21水平与2型糖尿病患者合并冠心病的相关性研究

Relationship between serum FGF-21 levels and type 2 diabetes combined with coronary artery disease

目的：评价血清成纤维细胞生长因子-21（FGF-21）的水平与2型糖尿病患者合并冠心病的相关性。方法将146名2型糖尿病患者分为合并冠心病组（66例）及未合并冠心病组（80例），采酶联免疫吸附法测定并比较两组血清FGF-21水平，采用Logistic回归分析评价FGF-21与合并冠心病的独立相关性。结果合并冠心病组高密度脂蛋白水平较未合并冠心病组明显降低，血清FGF-21水平较未合并冠心病组明显升高（t分别=3.89、-5.08，P均＜0.05），多元Logistic回归分析结果显示高血清FGF-21水平与合并冠心病存在独立正相关关系（OR=1.65，95% CI为1.13～2.64）。结论高血清FGF-21水平是2型糖尿病患者合并冠心病的独立危险因素，FGF-21可能是评估2型糖尿病患者冠心病风险重要的生物学标记物。

Objective To evaluate the relationship between fibroblast growth factor-21（FGF-21） levels and type 2 dia-betes（T2DM）combined with coronary artery disease（CAD）. Methods One hundred and forty-six T2DM patients were di-vided into two groups： patients with CAD and patients without CAD. Serum FGF-21 levels were detected by enzyme-linked immunosorbent assay（ELISA）. The association between serum FGF-21 levels and T2DM combined CAD was inves-tigated by logistic analysis. Results The high density lipoprotein in patients with CAD was significantly lower than that in patients without CAD while serum FGF-21 levels was significantly higher than that in patients without CAD （t=3.89,-5.08, P〈0.05）. Multivariate logistic regression demonstrated that serum FGF-21 levels was independently positive related with T2DM combined with CAD （OR=1.65, 95%CI 1.13~2.64）. Conclusion Higher FGF-21 in serum was an independent risk factor for T2DM combined with CAD. FGF-21 might be a promising biomarker for predicting the risk of CAD in T2DM patients.