TGF-β_1/Smads信号通路在高血压心肌纤维化中的调控机制研究进展被引量：22

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摘要心肌纤维化（MF）是多种心血管疾病引发的病理损害,高血压是引发MF最主要的原因之一,MF是高血压导致心室重构的基本特征.形成高血压MF的机制较为复杂,受多种细胞生长因子的调控,并与肾素—血管紧张素—醛固酮系统（RAAS）有关.在高血压MF形成过程中,转化生长因子β1（TGF-β1）是与高血压MF的形成关系最密切的细胞因子之一,TGF-β1可促进胶原基因表达和心肌成纤维细胞的转化,进而导致心肌细胞外基质（ECM）合成、沉积增加,最终导致MF[1,2].TGF-β1/Smads信号传导途径与MF有着密切的关系,其通路的异常活化参与人类多种脏器纤维化的发病过程.本文对TGF-β1/Smads信号通路与高血压MF之间的关系及中医药防治高血压MF现状进行探讨,希望为高血压MF的中医药防治提供理论基础.

作者张国华

机构地区南方医科大学中医药学院

出处《山东医药》 CAS 2014年第7期85-87,共3页 Shandong Medical Journal

基金国家自然科学基金资助项目(81072937 81373811)

关键词 TGF-Β1 SMADS信号通路高血压病心肌纤维化

分类号 R542.2 [医药卫生—心血管疾病]

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