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钙蛋白酶小亚基1与肿瘤发生发展的关系研究进展 被引量：1

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摘要 钙蛋白酶（calpains）是一种胞内半胱氨酸蛋白酶,主要由胞内Ca2＋浓度的升高所激活.近年研究发现calpains与肿瘤细胞凋亡有关,活化后的calpains可通过剪切有关凋亡分子蛋白如Bcl-2、Bax、Bid和p53等,以及直接剪切并活化caspase-3、caspase-7等方式,从而参与调控肿瘤细胞凋亡的病理过程.calpains是由大小2个亚基共同构成,28道尔顿的钙蛋白酶小亚基1（calpain-s1,capn4）是其调节性小亚基,与80道尔顿的大亚基以异二构体的形式存在.capn4与肿瘤的关系日益受到重视[1-3].现将近年来有关capn4与肿瘤发生发展的关系做一综述.
作者 庄乾锋 许贤林 何小舟
机构地区 苏州大学第三附属医院
出处 《山东医药》 CAS 2014年第7期91-93,共3页 Shandong Medical Journal
关键词 钙蛋白酶 钙蛋白酶小亚基1 肿瘤转移 肿瘤复发
分类号 R73 [医药卫生—肿瘤]
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参考文献27

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共引文献14

同被引文献15

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山东医药
2014年 第7期

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